Award
National Institute of General Medical Sciences 5R35GM118089-10
Integrative Structural Biology in DNA Replication and Damage Response
Recipient
Vanderbilt University
Award Amount
$435,875.00
Ceiling
$435,875.00
Awarded
January 14, 2026
Identifier
5R35GM118089-10
NIH grant awarded to Vanderbilt University for research on DNA replication and damage response using integrative structural biology techniques.
Description
This project aims to elucidate the structural mechanisms of DNA replication and damage response machinery using an integrative structural biology approach, including cryo-electron microscopy (Cryo-EM), biochemical, and biophysical methods. Key focus areas include structural analysis of DNA polymerase alpha-primase complex and mechanisms of replication fork stalling, reversal, and stabilization involving various proteins. The research will enhance understanding of DNA processing at eukaryotic replication forks and genome maintenance.