Award
NIH Reporter #1R01AA033111-01
Histone Acetylation and Synaptic Mechanisms in D1-MSNs Underlying Resilience to Compulsive-like Alcohol Drinking
Recipient
ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI, NY, UNITED STATES
Award Amount
$3,112,314.00
Ceiling
$3,112,314.00
Awarded
July 30, 2026
Identifier
1R01AA033111-01
The award supports research to elucidate molecular and synaptic mechanisms in D1-type medium spiny neurons that promote resilience to compulsive alcohol drinking, focusing on the role of histone acetylation and Sirt7 in the dorsomedial striatum.
Description
This project investigates epigenetic and synaptic mechanisms, focusing on histone acetylation and synaptic plasticity in D1-type medium spiny neurons, to understand resilience to compulsive alcohol drinking. It involves training mice to self-administer alcohol and evaluating behavior in response to aversive stimuli, with a focus on the role of Sirt7 in the dorsomedial striatum.