Award
National Institute of Diabetes and Digestive and Kidney Diseases 5R00DK129705-05
Controlling renal oxidative stress in CKD via targeting FGF23 bioactivity
Recipient
Jackson Laboratory
Award Amount
$249,000.00
Ceiling
$249,000.00
Awarded
July 31, 2025
Identifier
5R00DK129705-05
Research project funded by NIDDK to study molecular pathways involving Klotho and FGF23 to control renal oxidative stress in CKD, aiming to find new therapeutic targets.
Description
This project aims to enhance computational skills to identify how interactions of Klotho and its ligand fibroblast growth factor 23 (FGF23) protect against oxidative stress at the molecular level in chronic kidney disease (CKD). The studies will help identify new pathways regulated by Klotho and FGF23 that may slow CKD progression and uncover novel therapeutic targets.