Award
National Cancer Institute 11320762
PBRM1 bromodomain missense mutations in ccRCC vascular signaling
Recipient
MEDICAL COLLEGE OF WISCONSIN
Award Amount
$52,204.00
Ceiling
$52,204.00
Awarded
May 01, 2026
Identifier
11320762
Research project funded by the National Cancer Institute to study PBRM1 bromodomain mutations in ccRCC, focusing on mutation effects and vascular signaling, awarded about $52,204 for 2023-2028.
Description
This is a research project funded by the National Cancer Institute, focusing on the biochemical impacts of PBRM1 bromodomain missense mutations in clear cell renal cell carcinoma (ccRCC). The project aims to identify benign or deleterious mutations, assess their effects on protein stability and histone binding, and explore their role in regulating HIF-2α and angiogenesis pathways. The award amount is approximately $52,204, with a project duration from May 1, 2023, to April 30, 2028. The project is part of a fellowship addressing knowledge gaps in ccRCC pathogenesis and aims to promote precision medicine approaches.