Award
National Cancer Institute 1ZIABC012205-01
Structure and Functional Consequences of Serine vs. Threonine Mucin-Type O-linked Glycosylation
Recipient
DIVISION OF BASIC SCIENCES - NCI
Award Amount
$472,388.00
Ceiling
$472,388.00
Awarded
October 01, 2023
Identifier
1ZIABC012205-01
This NIH-funded project investigates the structural and functional differences in mucin-type O-linked glycosylation on serine versus threonine residues, focusing on implications for pancreatic tumor targeting through immunogen design.
Description
The project aims to define structural features of glycopeptides, study substrate specificity of MUC4 peptides with GALNTs, and analyze tumor-associated MUC4 glycans via mass spectrometry to develop targeted immunogens for pancreatic cancer.