Award
NIH Reporter #5F31CA306147-02
Dysregulated DNA replication forks as targets for formaldehyde mutagenesis
Recipient
Medical University of South Carolina
Award Amount
$48,215.00
Ceiling
$48,215.00
Awarded
July 29, 2026
Identifier
5F31CA306147-02
Research project funded by the National Cancer Institute to study how formaldehyde causes mutations at DNA replication forks, aiming to identify at-risk individuals and track environmental exposure.
Description
The project aims to investigate replication forks as a cellular source of single-stranded DNA targeted by formaldehyde, using yeast mutational reporters and human cell models. The research will identify individuals at risk for formaldehyde-induced carcinogenesis and establish a mutational signature for environmental exposure tracking.