Award
National Institute of General Medical Sciences 5R01GM149666-04
The roles of p53 and MYC dynamics in regulating heterogeneous cell fate responses to genotoxic stress
Recipient
University of Minnesota
Award Amount
$324,260.00
Ceiling
$324,260.00
Awarded
January 16, 2026
Identifier
5R01GM149666-04
NIH grant awarded to University of Minnesota to study how p53 and MYC dynamics regulate cell fate responses to genotoxic stress, with implications for cancer therapy.
Description
This project aims to understand how the dynamic regulation of signal transduction systems controls cellular stress responses, focusing on the transcription factors p53 and MYC. It investigates how their variable dynamics contribute to heterogeneous responses to DNA damage, which is critical for understanding tumor heterogeneity and therapy evasion. The study will use time-lapse fluorescence microscopy and quantitative analysis at the single-cell level across different cell conditions.