Award
National Heart, Lung, and Blood Institute 1F31HL184588-01
SGK1: A novel target for atrial myopathy in HFpEF
Recipient
Utah State Higher Education System--University of Utah
Award Amount
$40,907.00
Ceiling
$40,907.00
Awarded
May 19, 2026
Identifier
1F31HL184588-01
The award supports research on SGK1's role in atrial myopathy and atrial fibrillation in HFpEF, aiming to develop a novel SGK1-inhibitory peptide therapy.
Description
This project aims to decipher the molecular mechanisms contributing to atrial fibrillation (AF) in response to heart failure with preserved ejection fraction (HFpEF), focusing on the role of serum glucocorticoid regulated kinase 1 (SGK1) in atrial remodeling and AF inducibility. The study involves atrial-specific gene targeting of SGK1 in a mouse model of HFpEF and evaluates a novel SGK1 inhibitory peptide as a potential therapeutic intervention.