Award
NIH Reporter #5P01HL139420-08
Structural Correlates of (Pro)Cofactor Function
Recipient
Children's Hospital of Philadelphia, Philadelphia, PA, United States
Award Amount
$491,683.00
Ceiling
$491,683.00
Awarded
July 24, 2026
Identifier
5P01HL139420-08
Research project funded by the National Heart Lung and Blood Institute to study the structure and function of Factor V in blood coagulation, aiming to develop novel therapeutic interventions.
Description
The project aims to understand the structural and functional mechanisms of Factor V (FV) in blood coagulation, focusing on the B-domain's role in regulating procoagulant and anticoagulant activities. The research involves atomic force microscopy to determine the B-domain structure, investigating proteolytic effects, and developing antibodies to modulate FV functions.