Award
National Institute on Aging 1R21AG095657-01
Genetic insight into senescence from the Drosophila brain
Recipient
University of Pennsylvania, Philadelphia, PA, United States
Award Amount
$446,875.00
Ceiling
$446,875.00
Awarded
August 05, 2025
Identifier
1R21AG095657-01
A research project funded by the National Institute on Aging to study cellular senescence in the brain using Drosophila models, with the goal of understanding pathways that contribute to brain aging and neurodegenerative diseases.
Description
This project aims to understand senescence in vivo using Drosophila models, focusing on pathways involving the AP1 transcription factor complex and mitochondrial decline in neurons and glia. It involves genetic screens in Drosophila to identify genes that modulate senescence in neurons and glia, aiming to uncover pathways critical for brain aging and age-related diseases.