Award
National Institute on Aging 1R21AG095654-01
The impact of tau on RNA and translation in progressive supranuclear palsy
Recipient
University of Florida
Award Amount
$422,125.00
Ceiling
$422,125.00
Awarded
May 25, 2026
Identifier
1R21AG095654-01
Research project funded by the National Institute on Aging to study the impact of tau protein on RNA and translation in neurodegenerative diseases, aiming to identify therapeutic targets for tau-related neurodegeneration.
Description
This project aims to understand how the protein tau affects memory and neuronal function in tauopathies such as Alzheimer’s Disease and Progressive Supranuclear Palsy (PSP). It investigates the association of tau with the translation machinery, including ribosomes and mRNA, and how these interactions impair protein synthesis critical for memory. The research uses human brain tissues, in vitro, and in vivo models to study tau-RNA interactions and translation regulation.