Award
National Institute of General Medical Sciences 5R35GM124847-10
Protein Allostery and Catalysis Beyond Bragg Diffraction
Recipient
Cornell University, Ithaca, NY, United States
Award Amount
$412,907.00
Ceiling
$412,907.00
Awarded
July 28, 2026
Identifier
5R35GM124847-10
This award supports interdisciplinary research to visualize and understand protein dynamics and their functional roles using advanced imaging and computational techniques.
Description
The project aims to understand how protein motion gives rise to function by developing new computational methods to process data representing conformational disorder and mapping structural interconversions of allosteric and flexible enzymes. It integrates cryo-EM with advanced X-ray methods to capture correlated motions in allosteric networks, analyze conformational heterogeneity, and probe protein motions that control catalysis.