Award
National Institute of General Medical Sciences 5R16GM153621-03
Structural dynamics and energy landscapes of G protein signaling
Recipient
California State University Northridge
Award Amount
$147,500.00
Ceiling
$147,500.00
Awarded
June 16, 2026
Identifier
5R16GM153621-03
The award supports research on the structural dynamics and energy landscapes of G protein signaling, using computational and experimental methods to understand G protein activation mechanisms and signaling pathways.
Description
This project aims to provide mechanistic insights into G protein signaling using computational and experimental methods, with a focus on structural determinants and thermodynamics. It leverages experimental structures and computational approaches like molecular dynamics to understand G protein activation mechanisms, focusing on structural determinants and thermodynamic landscapes for G protein coupling, GDP release, dissociation, and ligand effects.