Award
National Heart, Lung, and Blood Institute 1R01HL182812-01
Using State-of-the-Art Technologies and Murine Models for Novel cGVHD Therapies
Recipient
University of Minnesota, Minneapolis, MN
Award Amount
$1,577,069.00
Ceiling
$1,577,069.00
Awarded
June 01, 2026
Identifier
1R01HL182812-01
This award funds research to understand chronic graft-versus-host disease mechanisms and develop novel antifibrotic therapies using advanced molecular and cellular techniques in mouse models.
Description
The project aims to acquire new insights into chronic GVHD (cGVHD) pathobiology to create new therapies to limit fibrosis. It involves using state-of-the-art techniques in valid mouse models to expose cGVHD vulnerabilities, spatially and temporally resolving and integrating proteomics with whole genome transcriptomics at a single-cell resolution within histopathological regions of interest, resulting in a spatiotemporal atlas mapping how specific cells drive cGVHD disease progression in both lymphoid and target tissues.