Award
National Institute of General Medical Sciences 11227094
Polarized Exocytosis: Rabs, Tethers, and SNAREs
Recipient
University of North Carolina at Chapel Hill, NC
Award Amount
$457,456.00
Ceiling
$457,456.00
Awarded
August 21, 2025
Identifier
11227094
Research project funded by NIGMS to study cellular mechanisms of polarized exocytosis and cell polarity, with implications for cancer and diabetes treatment development.
Description
Investigation into the fundamental mechanisms by which cells direct polarized growth, relevant to understanding diseases including tumor development and Type II diabetes. The project aims to understand regulation and coordination of exocytosis and cell polarity, focusing on molecular mechanisms involving Rho/Cdc42 GTPases, the exocyst, and Sro7/Tomosyn family members, with applications in yeast, mammalian systems, and mouse adipocyte models.