Award
National Institute of General Medical Sciences 2R35GM138186-06
Quantifying Physiologic and Pathologic Viscoelastic Phases of Biomolecular Condensates by Correlative Force and Fluorescence Microscopy
Recipient
State University of New York at Buffalo, Amherst, NY, United States
Award Amount
$2,161,607.00
Ceiling
$2,161,607.00
Awarded
August 18, 2025
Identifier
2R35GM138186-06
The award supports research to investigate the viscoelastic properties and phase transitions of biomolecular condensates using advanced microscopy and nanorheology techniques, aiming to elucidate mechanisms relevant to neurodegeneration and cancer.
Description
This project aims to understand the biophysical mechanisms, function, and disease processes mediated by biomolecular condensates by probing condensate microenvironments, mapping RNA phase separation, and detecting sequence-specific grammars in disordered prion-like domains. The research focuses on the material properties and aging dynamics of multi-component condensates in living cells, with implications for neurodegenerative disorders and cancer.