Award
National Institute of Allergy and Infectious Diseases 4R01AI099222-14
Regulation of host innate and adaptive immunity by bacterial type III effectors
Recipient
Dartmouth College, Hanover, NH, United States
Award Amount
$856,414.00
Ceiling
$856,414.00
Awarded
August 15, 2025
Identifier
4R01AI099222-14
Research grant to study how bacterial type III effectors inhibit host immune responses, focusing on Yersinia species and inflammasome inhibition to understand bacterial virulence mechanisms.
Description
This project aims to determine how effectors in virulent Yersinia species inhibit the pyrin inflammasome in vivo, focusing on effectors YopM and YopJ. The study will explore their role in inhibiting inflammasome activation in neutrophils within pyogranulomas, and how this promotes Yersinia virulence.