Award
National Institute on Aging 5R01AG089192-02
Multidimensional predictive modeling to understand mechanisms of exercise response heterogeneity in older adults
Recipient
Florida Institute / Human / Machine Cognition
Award Amount
$1,470,001.00
Ceiling
$1,470,001.00
Awarded
August 08, 2025
Identifier
5R01AG089192-02
A NIH-funded project to study and model the biological and molecular factors influencing exercise response variability in older adults, aiming to develop personalized interventions to improve health outcomes.
Description
This project aims to use combined endurance and resistance training aligned with public health guidelines to better understand the factors underlying variability in exercise response among older adults, focusing on aging hallmarks such as proteostasis, mitochondrial function, inflammation, and circadian clock regulation. The study involves a two-phase SMART trial with clinical phenotyping and molecular analyses to classify responders and non-responders, and to develop targeted interventions to improve exercise responsiveness.