Award
National Institute on Aging 5R01AG054159-09
Quantitative Neuroimaging Assessment of White Matter Integrity in the Context of Aging and AD
Recipient
Medical University of South Carolina, Charleston, SC, United States
Award Amount
$985,752.00
Ceiling
$985,752.00
Awarded
January 09, 2026
Identifier
5R01AG054159-09
This NIH-funded project aims to study white matter microstructure changes in aging and Alzheimer's Disease using advanced diffusion MRI to develop biomarkers and support therapeutic trials.
Description
The goal of this project is to elucidate the changes in white matter microstructure that signal the shift from healthy to pathological brain aging using advanced diffusion MRI methods. Expected outcomes include clinically feasible MRI biomarkers to empirically test models of white matter-related changes in aging and Alzheimer’s Disease (AD), supporting trials of myelin/glia-focused therapies underexplored for asymptomatic AD. The study aims to impact the understanding of how aging leads to AD and how it can be prevented or treated.