Award
NIH Reporter #5R01ES033630-05
Modeling the interaction of physiological and environmental stressors on common variants to psychiatric traits
Recipient
Yale University
Award Amount
$979,068.00
Ceiling
$979,068.00
Awarded
December 16, 2025
Identifier
5R01ES033630-05
A research project funded by the National Institute of Environmental Health Sciences to study the interaction of genetic variants and environmental stressors on psychiatric and neurodegenerative disorders, aiming to improve disease risk prediction and therapeutic strategies.
Description
This project aims to evaluate psychiatric and neurodegenerative risk variants, investigating their relationships with stress across major brain cell types and contexts. The study will dissect the regulatory impact of genetic variants, explore additive effects at the network and cellular levels, and assess clinical consequences across large biobanks to advance precision medicine by predicting disease trajectories and therapeutic interventions based on genetic and environmental interactions.