Award
National Institute of Allergy and Infectious Diseases (NIAID) 1R01AI192378-01
Persistent Immunogenicity of IDLV delivering Gag and membrane tethered HIV-1 Envelope Trimers
Recipient
Duke University, Durham, NC, United States
Award Amount
$791,661.00
Ceiling
$791,661.00
Awarded
July 31, 2025
Identifier
1R01AI192378-01
The award supports research to optimize an HIV vaccine using Integrase-Defective Lentiviral Vectors to deliver antigens that induce durable neutralizing antibodies and T cell responses, aiming to halt HIV-1 infection spread.
Description
This project aims to develop a vaccine platform that induces long-lasting immune responses against HIV-1 using IDLV vectors expressing Gag and stabilized Env trimers, with a focus on immune response durability and protection in non-human primate models.