Award
National Institute of Neurological Disorders and Stroke 1U19NS138975-01
Discovery and/or Validation of Pharmacodynamic Markers
Recipient
University of North Carolina at Chapel Hill, Chapel Hill, NC, United States
Award Amount
$807,274.00
Ceiling
$807,274.00
Awarded
September 18, 2024
Identifier
1U19NS138975-01
This NIH grant funds research to develop pharmacodynamic markers for NTSR1 target engagement in pain treatment, including pre-clinical assays and PET imaging agents.
Description
Research Component (RC) 4 focuses on developing pharmacodynamic (PD) markers to indicate molecular target engagement of pain assets, particularly targeting NTSR1. Goals include developing pre-clinical PD markers, measuring NTSR1 occupancy in the human brain, and creating PET imaging agents for real-time tracking of NTSR1 binding in the CNS.