Award
NIH Reporter #5R35GM136128-07
Regulation and Role of Phosphatidate Phosphatase in Lipid Metabolism
Recipient
Rutgers, The State University of New Jersey, Piscataway, NJ, United States
Award Amount
$431,750.00
Ceiling
$431,750.00
Awarded
May 20, 2026
Identifier
5R35GM136128-07
This award funds research on the regulation and role of phosphatidate phosphatase in lipid metabolism, focusing on its enzymatic regulation and implications for metabolic diseases.
Description
The project investigates the regulation and function of phosphatidate phosphatase (PAP), a conserved enzyme involved in lipid homeostasis, membrane synthesis, and metabolic disorders. The research aims to understand the enzyme's regulation via phosphorylation/dephosphorylation, its translocation between cellular compartments, and its role in diseases such as obesity, lipodystrophy, and diabetes.