Award
National Institute of Arthritis and Musculoskeletal and Skin Diseases 5K08AR082031-04
Modifying adipocyte and pre-adipocyte cell fate in fibroadipose tissue of secondary lymphedema
Recipient
Brigham and Women's Hospital
Award Amount
$172,760.00
Ceiling
$172,760.00
Awarded
March 03, 2026
Identifier
5K08AR082031-04
Research project funded by NIAMS to study adipocyte biology and develop cell therapies for secondary lymphedema, aiming to improve treatment and prevention strategies.
Description
This project aims to examine how signaling mediators influence adipocyte differentiation and stem cell proliferation, investigate how inhibition of pro-survival mediators affects adipocyte and pre-adipocyte survival and apoptosis, and develop local cell therapies secreting microRNA to avoid systemic adverse effects. The project will utilize lineage-tracing mouse models, single-cell RNA sequencing, and bioinformatics to establish expertise in adipocyte biology, cell therapy, and lymphedema, contributing to scientific advancement.