National Institute of General Medical Sciences 1R35GM164085-01

Dissecting the regulatory networks involved in elongation, division, and cell wall homeostasis in polarly growing bacteria

The award funds research to understand bacterial cell wall synthesis and regulation in polarly growing bacteria, aiming to identify new antibiotic targets, especially against zoonotic pathogens like Brucella.

Description

This project explores the mechanisms underlying unipolar growth and cell division during cell cycle progression, as well as the genetic interactions and pathway rewiring that enable cell wall resilience to stress in the Hyphomicrobiales. The research aims to understand the genetic determinants that govern polar cell-wall biogenesis in coordination with the cell cycle and in response to environmental conditions, using Agrobacterium tumefaciens as a model. The goal is to reveal new targets for taxa-specific antibiotics, including zoonotic pathogens such as Brucella.

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