Award
NIH Reporter #1ZIAAG000582-04
ALZHEIMERS RESEARCH PROJECT: B cells promote Alzheimers disease via cytolytic CD8+ T cells
Recipient
National Institute on Aging, United States
Award Amount
$158,970.00
Ceiling
$158,970.00
Awarded
April 27, 2024
Identifier
1ZIAAG000582-04
The project studies the immune mechanisms in Alzheimer's disease, highlighting the contribution of B cells in promoting disease progression via activation of CD8+ T cells and impairment of microglial function, leading to neurodegeneration.
Description
This research project investigates the role of B cells and CD8+ T cells in Alzheimer's disease pathology, focusing on how B cells promote neurodegeneration through interactions with CD8+ T cells and microglia, and the formation of ectopic lymphoid structures in the meninges.