Award
National Heart, Lung, and Blood Institute 5R01HL171206-03
Mechanistic dissection of 22q11.2DS in zebrafish
Recipient
Boston Children's Hospital, Boston, MA, United States
Award Amount
$608,808.00
Ceiling
$608,808.00
Awarded
March 11, 2026
Identifier
5R01HL171206-03
The award supports research using zebrafish models to study the role of the Tbx1 gene in cardiovascular development and congenital heart defects associated with 22q11.2 deletion syndrome.
Description
This project uses zebrafish tbx1 mutants as a model to uncover how Tbx1 regulates cardiovascular development, aiming to understand congenital heart defects in 22q11.2 deletion syndrome (22q11.2DS). The research focuses on the molecular mechanisms by which Tbx1 directs specification of the pharyngeal progenitor cell lineage during vertebrate development.