Award
NIH Reporter #5K23EY037861-02
Genetic Variation in AMD Progression and Treatment Response
Recipient
University of California Los Angeles
Award Amount
$244,379.00
Ceiling
$244,379.00
Awarded
April 09, 2026
Identifier
5K23EY037861-02
Research project funded by the National Eye Institute to study genetic variation effects on AMD progression and treatment response using AI and ML techniques applied to OCT imaging and genetic data.
Description
This project aims to explore how genetic variation influences disease progression and therapeutic response in age-related macular degeneration (AMD) by integrating advanced optical coherence tomography (OCT) imaging with machine learning (ML) and artificial intelligence (AI). The project leverages ML for deep phenotyping of OCT data to refine the classification of AMD subtypes, combined with genetic analysis for a deeper understanding of disease progression. The hypothesis is that genetic variations influence distinct AMD subtypes and stages, shaping both disease progression and therapeutic response.