Award
NIH Reporter #5R01GM143183-04
Structural characterization of single, double and triple-headed axonemal dyneins
Recipient
Harvard Medical School, Boston, MA, United States
Award Amount
$353,121.00
Ceiling
$353,121.00
Awarded
July 14, 2025
Identifier
5R01GM143183-04
The award funds research to determine the structures and functions of axonemal dyneins, which are critical for ciliary motility. The project uses cryo-EM and biochemical methods to study dynein complexes from various organisms, aiming to inform therapies for cilia-related diseases.
Description
This project aims to reveal the detailed structures of the multiple dynein motors that power ciliary motility, helping to identify key aspects of their assembly and function that could be targeted for novel therapies of cilia dysfunction. Motile cilia are microtubule-based organelles that produce a driving force for cellular locomotion and extracellular fluid flow. In humans, paralyzed or dyskinetic cilia can lead to infertility, chronic respiratory disease, and laterality abnormalities.