Award
National Institute of Diabetes and Digestive and Kidney Diseases 1R01DK143462-01A1
A gut sense for dietary lysine
Recipient
Duke University, Durham, NC, United States
Award Amount
$637,471.00
Ceiling
$637,471.00
Awarded
March 18, 2026
Identifier
1R01DK143462-01A1
Research project funded by NIDDK to study how the gut senses dietary lysine and influences feeding behavior, with potential applications in malnutrition and obesity management.
Description
The project aims to define a neural circuit by which the gut detects the presence of dietary lysine and drives lysine consumption when it is absent in the diet. The research focuses on the role of duodenal neuropod cells in sensing lysine and signaling to the brain via the vagus nerve, with implications for managing protein malnutrition and obesity.