# NIH Reporter #5R01HL163857-04

Premature aging disorders, metabolites, and atherosclerosis

**Recipient:** UNIVERSITY OF TX MD ANDERSON CAN CTR

**Award Amount:** $691,393.00
**Ceiling:** $691,393.00

**Awarded:** February 16, 2026

**Identifier:** 5R01HL163857-04

The project investigates molecular mechanisms linking premature aging-related vascular diseases to atherosclerosis, focusing on metabolite pathways and the PKCζ-TOP2β and PARP pathways.

### Description

NIH research project examining how premature senescence-triggered vascular diseases and Hutchinson-Gilford progeria syndrome affect metabolites, endothelial cell dysfunction, and atherosclerosis.

[View original record](https://reporter.nih.gov/search/J7l2tQ4hHkqRePwGq3m5kA/project-details/11228780)