Award
National Institute of Allergy and Infectious Diseases 5R21AI183017-02
Interrogating mucosal resident memory CD8 T cell biology with 3D organoids
Recipient
Brown University, Providence, RI
Award Amount
$198,029.00
Ceiling
$198,029.00
Awarded
April 01, 2025
Identifier
5R21AI183017-02
Research grant to study mucosal resident memory CD8 T cells in the female reproductive tract using 3D organoid models to understand molecular mechanisms of T cell differentiation.
Description
This project aims to use a novel 3D vaginal epithelial organoid-CD8 T cell coculture system to investigate the molecular interactions necessary for TRM differentiation. The study will identify key transcription factors and signaling pathways, including the role of retinoic acid, in promoting TRM formation.