Award
NIH Reporter #5K08AI163381-05
Immunoproteomic mechanisms of human macrophage resistance to Mycobacterium tuberculosis infection
Recipient
University of Washington
Award Amount
$187,920.00
Ceiling
$187,920.00
Awarded
August 20, 2025
Identifier
5K08AI163381-05
Research project funded by the National Institute of Allergy and Infectious Diseases to study proteomic mechanisms of human macrophage resistance to tuberculosis infection, focusing on host-directed therapies.
Description
This project aims to uncover proteomic determinants of macrophage resistance to Mycobacterium tuberculosis (Mtb) infection. It involves proteomic, bioinformatic, and cellular immunology approaches to identify key pathways in human macrophage resistance that can be targeted with host-directed therapies. The research includes investigating Rab-dependent mechanisms, post-translational modifications, and ubiquitin-dependent mechanisms of resistance.