Award
National Institute on Aging 4RF1AG078245-02
Vascular contribution to white matter lesions and motor dysfunction in AD and ADRD
Recipient
Rutgers Biomedical and Health Sciences, Newark, NJ, United States
Award Amount
$1,226,883.00
Ceiling
$1,226,883.00
Awarded
September 03, 2025
Identifier
4RF1AG078245-02
Research project funded by the National Institute on Aging to study vascular contributions to white matter lesions and motor dysfunction in Alzheimer's Disease and related dementias, using postmortem analysis and rodent models to understand mechanisms and develop therapeutics.
Description
The study aims to analyze postmortem brain tissues of AD patients with early motor deficits and investigate the pathogenic mechanisms of motor dysfunction in rodent models of AD and FDD using biochemical, histological, genetic, and advanced MRI techniques. The hypothesis suggests that fibrin deposits and vascular degeneration lead to blood-brain barrier damage, inflammation, demyelination, axonal degeneration, and ultimately motor dysfunction.