Award
National Heart, Lung, and Blood Institute 5R01HL146626-08
Regulation of cardiac pacemaker cell cytoarchitecture
Recipient
University of North Carolina Chapel Hill
Award Amount
$589,642.00
Ceiling
$589,642.00
Awarded
April 08, 2026
Identifier
5R01HL146626-08
The project investigates the molecular and cellular mechanisms regulating cardiac pacemaker cells to understand normal function and disease-related disruptions, aiming to inform therapeutic strategies.
Description
This project aims to define the cellular interactions maintaining normal sinoatrial node function, uncover homeostatic processes supporting cardiac pacemaking, and identify disruptions in disease. The study focuses on molecular pathways that produce a microenvironmental niche around pacemaker cells (CPCs), involving biomechanical compliance and paracrine signaling, and how these interactions change with aging or disease.