Award
National Institute of Diabetes and Digestive and Kidney Diseases 5R01DK132264-05
Deciphering age-dependent beige adipocyte failure
Recipient
CORNELL UNIVERSITY
Award Amount
$448,009.00
Ceiling
$448,009.00
Awarded
January 28, 2026
Identifier
5R01DK132264-05
This award supports research to understand and reverse the decline in beige fat cell formation with age, which could improve metabolic health and combat obesity and type 2 diabetes in older adults.
Description
The project aims to decipher how aging disrupts beige fat development to revive beige fat, promote healthy fat tissue, and fuel metabolic fitness in aging humans. It investigates mechanisms blocking beige fat biogenesis in aged mammals, focusing on Pdgfrβ signaling, its regulation by sympathetic tone, and its impact on ILC2 recruitment and activation within white adipose tissue.