Award
National Institute of Diabetes and Digestive and Kidney Diseases 5R01DK138025-03
microRNA-controlled mRNA therapeutics
Recipient
ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI, NEW YORK, NY, USA
Award Amount
$559,205.00
Ceiling
$559,205.00
Awarded
January 16, 2026
Identifier
5R01DK138025-03
This NIH grant supports the development of modRNA therapeutics that use miRNA target sites to control protein expression in specific cell types, aiming to modulate immune responses and improve vaccine efficacy.
Description
The goal of this project is to establish novel modRNA formulations that tailor expression of proteins to specific cell types and determine how expression in specific cells directs immunity to modRNA-encoded protein. The project involves developing technology to control modRNA expression in different cell types using miRNA target sites, and studying how this affects immune response and vaccine efficacy.