Award
NIH Reporter #5UG3ES035689-02
Identification and optimization of medical countermeasures for phosgene inhalation injuries
Recipient
Duke University, Durham, NC
Award Amount
$554,354.00
Ceiling
$554,354.00
Awarded
August 14, 2025
Identifier
5UG3ES035689-02
A NIH-funded grant awarded to Duke University to develop targeted treatments for phosgene-induced lung injuries through preclinical testing of RAAS modulators and sEHIs in animal models, aiming for future BARDA and FDA approval.
Description
This project aims to identify and optimize therapeutic compounds that mitigate lung injury and inflammation caused by phosgene gas inhalation in mice and swine, facilitating future human treatment development under the US FDA animal rule. It targets the renin-angiotensin-aldosterone system (RAAS) and stimulates resolution pathways via soluble epoxide hydrolase inhibitors (sEHIs) to reduce lung injury and improve recovery.