Award
NIH Reporter #5R35GM154857-02
Pathways of peroxidation: defining the autoxidation of polyunsaturated fatty acids and the cellular consequences
Recipient
Louisiana State University A&M College
Award Amount
$369,174.00
Ceiling
$369,174.00
Awarded
July 29, 2025
Identifier
5R35GM154857-02
This award funds research to understand how polyunsaturated fatty acids undergo autoxidation and the resulting cellular effects, with the goal of identifying targets for treating inflammation-related diseases.
Description
Research project to characterize polyunsaturated fatty acid autoxidation in cells, elucidate molecular determinants of lipid electrophile formation, and identify protein targets of lipid electrophiles using Staphylococcus aureus as a model system. The study aims to define molecular interactions driving inflammation-associated diseases and validate targets for future therapies.