Award
National Institute of Allergy and Infectious Diseases 1R01AI194527-01A1
Investigating the nonlinear complex dynamics of the tuft cell-microbiome cross-talk: the impact of feedback loops on immune regulation, microbial modulation and response to tissue insults
Recipient
University of Massachusetts Medical School Worcester
Award Amount
$836,691.00
Ceiling
$836,691.00
Awarded
June 17, 2026
Identifier
1R01AI194527-01A1
NIH awarded a research grant to University of Massachusetts Medical School Worcester to study the complex interactions between tuft cells and the microbiome, focusing on immune regulation and response to tissue insults, using mathematical modeling and experimental data.
Description
The project investigates how tuft cells, goblet cells, Paneth cells, type 2 lymphocytes, and succinate-modulated microbial communities coordinate to maintain intestinal barrier resilience. Uses multi-scale mathematical modeling calibrated with longitudinal data from genetically modified mice and organoids. Aims to develop predictive, interoperable models to inform strategies to prevent or treat infectious and inflammatory colitis.