Veterans Health Administration 2I01BX005084-05

The terminal steps of cortisol and aldosterone biosynthesis

Research project awarded to study the biochemistry of enzymes involved in cortisol and aldosterone biosynthesis to develop selective inhibitors for improved treatment of related diseases.

Description

The project aims to dissect the biochemistry of enzymes P450 11B1 and P450 11B2 involved in cortisol and aldosterone biosynthesis. The research focuses on understanding enzyme processivity, binding, dissociation, and turnover to develop selective allosteric inhibitors. The project involves advanced biochemical and biophysical studies, including rapid kinetic studies and tandem mass spectrometry. The goal is to develop drugs that selectively inhibit specific enzyme reactions to improve treatment of related human diseases.

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