Award
National Institute of Allergy and Infectious Diseases 1R01AI179901-01A1
Human Airway Macrophage Immunity in Tuberculosis: Defining Early Determinants of Infection
Recipient
University of Minnesota, Minneapolis, MN, United States
Award Amount
$757,038.00
Ceiling
$757,038.00
Awarded
March 27, 2026
Identifier
1R01AI179901-01A1
Research project funded by NIAID to study early immune responses of human airway macrophages to tuberculosis infection, focusing on Type I Interferon pathways and their role in infection outcomes.
Description
This project aims to understand the innate immune responses of human airway macrophages to Mycobacterium tuberculosis (Mtb). It focuses on the role of Type I Interferon (IFN) pathways in TB progression and how early airway macrophage IFN responses influence initial infection outcomes. The study involves characterizing transcriptomic and epigenetic landscapes of airway macrophages using scRNA-seq and ATAC-seq, and establishing a cohort to examine associations between macrophage clusters and IGRA positivity following Mtb exposure.