Award
National Institute of Allergy and Infectious Diseases 1R21AI196587-01
Characterizing NLRP11 Activation by Mycobacteria to Enhance Innate Immune Responses
Recipient
University of Maryland, College Park, MD
Award Amount
$421,720.00
Ceiling
$421,720.00
Awarded
February 02, 2026
Identifier
1R21AI196587-01
Research project to study NLRP11/caspase-4 inflammasome recognition of mycobacteria to enhance innate immune responses and aid vaccine development.
Description
The project aims to characterize how the non-canonical NLRP11/caspase-4 inflammasome recognizes mycobacteria. The research involves screening mycobacterial species, identifying ligands, and discovering genes involved in recognition, with potential applications in vaccine development.