Award
National Cancer Institute 5R01CA259469-05
Systems biology of intratumoral heterogeneity in glioblastoma
Recipient
Institute for Systems Biology
Award Amount
$735,737.00
Ceiling
$735,737.00
Awarded
January 12, 2026
Identifier
5R01CA259469-05
This NIH grant supports research using systems biology to study gene networks involved in drug resistance and recurrence in glioblastoma, employing single-cell profiling and drug screening to develop targeted therapies.
Description
The project aims to use systems biology approaches to understand gene networks responsible for drug resistance and recurrence in glioblastoma. It will involve single-cell profiling (scRNA-seq and scATAC-seq) of patient-derived glioma stem-like cells (GSCs) across multiple FDA-approved drugs to elucidate mechanisms of drug-induced phenotypic transitions and identify potential combination therapies.