Award
NIH Reporter #1R21AI197150-01A1
Cytosolic copper ion accumulation and proteome integrity.
Recipient
Rutgers, The State Univ of N.J., Piscataway, NJ, United States
Award Amount
$421,889.00
Ceiling
$421,889.00
Awarded
September 02, 2026
Identifier
1R21AI197150-01A1
Research project funded by NIAID to study copper ion toxicity mechanisms in Staphylococcus aureus and bacterial resistance, with implications for antimicrobial strategies.
Description
This project aims to understand how copper ions kill Staphylococcus aureus and how toxicity is overcome, focusing on mechanisms like protein misfolding, aggregation, and the role of protein homeostasis machinery. It includes characterizing copper ion toxicity mechanisms, the role of protein homeostasis, mutations increasing copper tolerance, and synergy between molecular chaperone inhibitors and copper ions.