Award
National Institute of General Medical Sciences 7R01GM140183-05
Cascade Reactions for Biologically Active Natural Products
Recipient
TEMPLE UNIV OF THE COMMONWEALTH, PHILADELPHIA, PA, UNITED STATES
Award Amount
$253,019.00
Ceiling
$253,019.00
Awarded
April 25, 2025
Identifier
7R01GM140183-05
Development of cascade reactions to synthesize biologically active natural products, improving efficiency and addressing supply limitations of key pharmaceutical compounds like Homoharringtonine.
Description
This project aims to develop new cascade reactions to efficiently synthesize substituted arenes and complex polycyclic alkaloids, including Homoharringtonine (HHT), a clinically used protein translation inhibitor for leukemia treatment. The research focuses on eliminating supply problems by streamlining complex molecule synthesis, contributing to natural product-based drug development.