Award
University of Puerto Rico Medical Sciences Campus 5R16GM149491-04
BDNF in the Reward Circuit for DBS-Induced Opioid Extinction
Recipient
University of Puerto Rico Medical Sciences
Awarded
April 02, 2026
Identifier
5R16GM149491-04
Deep brain stimulation (DBS) is a neurosurgical procedure used to treat neurologic and psychiatric disorders. Recent research suggests DBS may be effective for refractory addiction. The project aims to understand DBS mechanisms and effects on drug-seeking behavior, with potential applications for reducing symptoms of addiction and opioid use disorders.
Description
This project involves research on deep brain stimulation (DBS) and its effects on drug-seeking behavior and opioid use disorder, including molecular and circuit-based approaches, pharmacological and chemogenetic methods, and neurobiological assessments.