Award
National Cancer Institute 5U54CA274516-03
Shared Resource Core 2: Clinical Artificial Intelligence Core
Recipient
Dana-Farber Cancer Institute, Boston, MA, United States
Award Amount
$91,073.00
Ceiling
$91,073.00
Awarded
September 19, 2023
Identifier
5U54CA274516-03
The project aims to develop AI pipelines for analyzing clinical data related to pediatric cancers, supporting research and clinical translation through standardized, reproducible methods.
Description
Artificial intelligence (AI) algorithms have the potential to fundamentally change medicine through their ability to recognize complex patterns in medical data. The Clinical Artificial Intelligence and Imaging Core (AI Core) is an essential shared resource that will support the Aims of the Harvard/UCSF ROBIN Research Projects to enable large-scale analysis of granular clinical data, allowing non-invasive characterization of tumoral and patient heterogeneity and a path towards clinical translation. This will be achieved through the following Specific Aims: Retrieve, curate, and annotate digitized clinical data to support quantitative analyses and AI/informatics pipelines for the ROBIN Molecular Characterization Trial and Research Projects, producing one of the most comprehensive datasets for DMG and neuroblastoma patients. Develop and evaluate task-specific AI pipelines using data preprocessing, AI-derived imaging biomarkers, and natural language processing platforms for tumor heterogeneity, radiation resistance/response, and toxicity characterization. Standardize and release AI/informatics methods across data types and applications to ensure transparency, reproducibility, and access, accelerating clinical translation.