Award
National Institute of Environmental Health Sciences 5R21ES036349-02
Interoceptive functions of airway brush cells
Recipient
Johns Hopkins University, Baltimore, MD, United States
Award Amount
$204,688.00
Ceiling
$204,688.00
Awarded
March 13, 2025
Identifier
5R21ES036349-02
Research project to understand how airway brush cells mediate reflexes like cough and bronchospasm by studying their activation and signaling mechanisms using transgenic and molecular techniques.
Description
The overall goal of this research is to better define the mechanisms by which airway mucosal irritation is transduced into airway defensive reflexes such as cough and bronchospasm. The study focuses on the role of brush cells in the airway epithelium and the actions of transmitters and mediators released by these cells.