Award
National Institute of Allergy and Infectious Diseases 1R56AI200599-01
Host Restriction of Immune Escape HIV-1 Mutants
Recipient
Mehary Medical College
Award Amount
$613,261.00
Ceiling
$613,261.00
Awarded
May 11, 2026
Identifier
1R56AI200599-01
NIH grant awarded to Mehary Medical College to study molecular mechanisms of HIV-1 immune escape and host restriction factors, aiming to inform HIV cure strategies.
Description
This project aims to understand the molecular mechanisms that enable HIV-1 to escape immune control in elite controllers, focusing on host dependency factors such as CypA, CPSF6, and TRIM5αhu. The research will investigate how these factors influence viral DNA integration and restriction, with potential implications for developing HIV cure strategies.